RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
let-7b
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
dual-luciferase reporter assay
Target
LIN28
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Repression of let-7 by transforming growth factor-beta1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions
Year
2018
Function
Lin28 as a new TGF-betatarget gene and suggest a novel role for the lin28/let-7 pathway in controlling TGF-beta-induced collagen accumulation in diabetic nephropathies.